The Week’s 10 Biggest Funding Rounds: Enterprise AI, Space Tech And Biotech Top The Ranks

Want to keep track of the largest startup funding deals in 2025 with our curated list of $100 million-plus venture deals to U.S.-based companies? Check out The Crunchbase Megadeals Board . This is a weekly feature that runs down the week’s top 10 announced funding rounds in the U.S. Check out last week’s biggest funding deal roundup here . Another week, another infusion of big AI rounds. For this past week, the largest fundraiser by a long shot was Sierra , a developer of AI customer experience tools that picked up $950 million. Other big rounds went to companies in sectors including satellite development, biotech, and, yes, more vertical AI and AI infrastructure. 1. Sierra , $950M, customer experience AI: Sierra, a provider of AI-driven tools for customer experience management, raised $950 million in fresh funding at a $15 billion valuation. Google Ventures and Tiger Global led the financing for the three-year-old, San Francisco-based company. 2. Astranis , $455M, space tech: Astranis, a developer of advanced satellites for high orbits, secured $450 million in equity and debt investment. The financing included a $300 million Series E equity round led by Snowpoint Ventures and Franklin Templeton and up to $155 million in credit through Trinity Capital . 3. Anagram Therapeutics , $250M, biotech: Natick, Massachusetts-based Anagram Therapeutics, a developer of a pill for people living with exocrine pancreatic insufficiency due to cystic fibrosis, pancreatic cancer and related disorders, closed on $250 million in new funding from Blackstone Life Sciences . 4. Blitzy , $200M, AI software development: Blitzy, developer of an autonomous software development platform, picked up $200 million in fresh funding at a $1.4 billion valuation. Northzone led the financing for the Cambridge, Massachusetts-based company. 5. Corgi Insurance , $160M, insurance: Corgi Insurance, provider of an AI-native insurance platform for startups, secured $160 million in Series B funding. TCV led the financing, which set a $1.3 billion valuation for the San Francisco-based company. 6. Panthalassa , $140M, renewable energy: Portland, Oregon-based Panthalassa, which aims to perform AI inference computing at sea using power generated from ocean waves, raised $140 million in a Series B financing led by Peter Thiel . 7. Reserv , $125M, insurance: Reserv, a provider of third-party administrator services to the insurance industry, closed on $125 million in a Series C funding round led by KKR . Launched in 2022, New York-based Reserv has raised over $200 million in known funding to date, per Crunchbase data. 8. DeepInfra , $107M, AI infrastructure: DeepInfra, a cloud platform for high-throughput AI inference, landed $107 million in Series B funding. Georges Harik and 500 Global led the financing for the four-year-old, Palo Alto, California-based company. 9. Tessera Labs , $60M, vertical AI: San Jose, California-based Tessera Labs, developer of an AI platform for enterprise ERP systems and data, secured $60 million in a funding round led by Andreessen Horowitz . 10. Astrocade , $56M, gaming: Astrocade, developer of an AI platform for creating, building and playing games, announced $56 million in new funding. The funding for the Los Altos, California-based company includes a Series B led by Sequoia Capital and a Series A led by Sea , Astrocade said. Illustration: Dom Guzman